Fish oil at 10-12 grams and 1.2 grams of docosahexaenoic acid has been shown to improve symptoms.
Wild cold- water fish (salmon, mackerel,or hering) plus 1 tbsp flaxseed oil daily may be advantageous because of the lipid peroxidases in many fish oil products.
EPA(eicosapentaenoic acid) improves psoriasis because of competitiion for arachidonic acid binding sites, inhibiting synthesis of inflamatory leukotrienes from arachodonic acid, which are elevated up to 800 times in psoriatic patients compared to non-psoriatic patients. A tissue-intrinsic unidentified inhibitor of cyclooxygenase is involved.
Cyclooxegenase inhibitors (asprin, nsaids) may exacerbate psoriasis. Lipoxygenase inhibitors(benoxyaprofen) may improve psoriasis. Natural substances ( quercetin, ubiquitous plant flavonoid), vitamin E, onion, and garlic inhibit lipoxygenase.
Arachadonic acid is found in animal fats and dairy so these substances should be limited. Psoriasis is also linked to body mass index and inversely related to intake of carrots, tomatoes, fresh fruits, and index of beta- arotene intake. Fasting and vegetarian regimens help psoriatics, probably because of decreased gut-derived toxins and polyamines. Gluten-free and elimination diets are beneficial. Justin Felsman
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